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Hidroacanthoma simplex: An ultrastructural and immunohistochemical study
Author(s) -
Perniciaro Charles,
Muller Sigfrid A.,
Zelickson Brian D.,
Snow John L.
Publication year - 1994
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1994.tb00273.x
Subject(s) - immunohistochemistry , immunostaining , carcinoembryonic antigen , pathology , keratin , ultrastructure , staining , electron microscope , antibody , antigen , neoplasm , biology , epithelium , eosinophilic , chemistry , medicine , immunology , cancer , physics , optics , genetics
A representative case of hidroacanthoma simplex was studied with routine light microscopy, immunohistochemistry, and electron microscopy. Staining with the periodic acid‐Schffi reagent and immunostaining with anti‐keratin antibodies were useful in demarcating the tumor cells from adjacent normal epithelium. However, antibodies to carcinoembryonic antigen and epithelial membrane antigen did not help us to segregate or identify the neoplastic cells. Electron microscopy revealed tumor cells markedly different in appearance from luminal cells of the acrosyringium. Hidroacanthoma simplex does not appear to be derived from luminal cells of the acrosyringium. We propose criteria for the histologic diagnosis of this benign neoplasm.