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HPV‐associated epithelial atypia in oral warts in HIV + patients
Author(s) -
Regezi Joseph A.,
Greenspan Deborah,
Greenspan John S.,
Wong Eileen,
MacPhail Laurie A.
Publication year - 1994
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1994.tb00263.x
Subject(s) - pathology , atypia , tongue , medicine , koilocyte , hpv infection , basal (medicine) , cervical intraepithelial neoplasia , cancer , cervical cancer , insulin
Reported are oral mucosal warts (HPV common antigen‐positive) from 7 adult HIV + patients in which there was cytologic atypia and disordered growth. Lesions were papillary, white to red in color, and were located on the lip, gingiya, palate, tongue, and buccal mucosa. Histologically, the keratinocytes in the lesions exhibited atypical features in the form of hyper‐chromatism and karyomegaly. Koilocytes were frequently seen in the upper level keratinocytes where HPV common antigen was identified. The dysplastic areas, which ranged from mild to severe, typically showed abrupt limiting margins. All lesions exhibited intense PCNA reactivity from basement membrane to surface. Nuclei of mid‐level and basal keratinocytes of 3 specimens stained positively for p53 protein. We believe that the atypia found in these lesions represents cytologic change that has malignant potential. The subtype of the HPV in these lesions has not yet been determined.