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Sinus histiocytosis (Rosai‐Dorfman disease) clinically limited to the skin
Author(s) -
Perrin C.,
Michiels J. F.,
Lacour J. P.,
Chag A.,
Fuzibet J. G.
Publication year - 1993
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1993.tb01278.x
Subject(s) - rosai–dorfman disease , histiocyte , factor xiiia , pathology , histiocytosis , medicine , s100 protein , immunophenotyping , immunohistochemistry , emperipolesis , sinus histiocytosis with massive lymphadenopathy , dermatopathology , disease , antigen , immunology
A case study of sinus histiocytosis of Rosai‐Dorfman (SH) clinically limited to the skin is presented with immunohistochemical study of the infiltrate, in both paraffin and cryostal sections. Factor XIIIa, a dendrocyte marker, was demonstrated in the cytoplasm of histiocytes. This feature had not been previously reported in this disease. In addition, the cells expressed S100 protein, CD4, CD la, GD68, and GD11c. This immunophenotyping study suggests that SH could affect the antigen‐presenting activity of Factor XIIIa cells, i.e., the skin dermal dendrocyte.