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Clear cell basal cell carcinoma: An unusual degenerative variant
Author(s) -
Barr Ronald J.,
Alpern Kenneth S.,
Santa Cruz Daniel J.,
Fretzin David F.
Publication year - 1993
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1993.tb01267.x
Subject(s) - basal cell carcinoma , pathology , cell , basal cell , biology , clear cell , carcinoma , cell of origin , basal (medicine) , medicine , genetics , endocrinology , insulin
Clear cell basal cell carcinoma (BCC) is an unusual variant of BCC which is characterized by a variable component of large clear cells. Twenty cases are presented which are further subdivided into pure, mixed, or metatypical categories. Although initially thought to represent sebaceous or tricholemmal differentiation, electron microscopic studies demonstrated that the clear cell changes are a degenerative phenomenon, probably involving lysosomes.