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Homeobox genes and the patterning of skin diseases
Author(s) -
Brown W. M.,
Stenn K. S.
Publication year - 1993
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1993.tb01264.x
Subject(s) - homeobox , biology , homeobox a1 , gene , homeobox protein nkx 2.5 , presentation (obstetrics) , neuroscience , genetics , computational biology , medicine , transcription factor , radiology
Fundamental to our understanding of skin diseases and their presentation is an understanding of the pattern of their development. When we have established the molecular basis of their development we will be in a much better position to control and treat such diseases. The homeobox genes are a family of regulatory proteins that influence pattern formation at many levels. Their presence in skin implicates them in this important role. It seems highly likely that they will be shown to be fundamental to the development of the patterns used in diagnosing skin diseases.