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Immunophenotypic analysis suggests that granuloma faciale is a γ‐interferon‐mediated process
Author(s) -
Smoller Bruce R.,
Bortz Jeff
Publication year - 1993
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1993.tb00668.x
Subject(s) - pathogenesis , immunoperoxidase , pathology , immunology , granuloma , population , antigen , antibody , medicine , biology , monoclonal antibody , environmental health
Granuloma faciale (GF) is an uncommon inflammatory dermatosis with characteristic clinical and histologic features. Very little is known about its pathogenesis. We used a battery of immunoperoxidase lymphocyte markers to study the population of hematopoetic cells present in a case of GF. The majority of non‐myelocytic hematopoetic cells present were T‐helper lymphocytes, The cells stained strongly with antibodies against the interleukin‐2 receptor and with anti‐lymphocyte functional antigen (LFA 1α) antibodies. Overlying keratinocytes did not stain with ICAM‐1 or HLA‐DR, which may account for the presence of the Grenz zone in granuloma faciale. These findings suggest that a γ‐interferon‐mediated process may play some role in the pathogenesis of this disorder.