Premium
In vitro acantholysis induced by D‐penicillamine, captopril, and piroxicam on dead de‐epidermized dermis
Author(s) -
Dobbeleer Gilbert,
Godfrine Sylvie,
Gourdain JeanMarie,
Graef Chantal,
Heenen Michel
Publication year - 1992
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1992.tb01656.x
Subject(s) - acantholysis , penicillamine , captopril , piroxicam , dermis , medicine , pemphigus , organ culture , in vitro , pathology , dermatology , chemistry , immunology , biochemistry , alternative medicine , antibody , blood pressure , autoantibody
Drug‐induced pemphigus has been recognized for 20 years, hui the mechanisms leading to acantholysis are still unclear. It has recently been demonstrated that penicillamine, captopril, and thiopronin may produce acantholytic lesions, cither by direct toxic or biochemical died, in human skin explains. Our work confirms that penicillamine and captopril may induce acantholysis on the model of keralinocyte culture on dead, de‐epidermized dermis. Moreover, it demonstrates that piroxicam, a new non‐steroidal anti‐inflammatory drug, of which one side effect is a pemphigus vulgaris‐like eruption, is also able to produce in vitro acantholysis.