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Neurotropic malignant melanoma occurring in a stable burn scar
Author(s) -
Lee Julia Y.Y.,
Kapadia Silloo B.,
Musgrave Ross H.,
Futrell William J.
Publication year - 1992
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1992.tb01357.x
Subject(s) - dermis , melanoma , pathology , medicine , epidermis (zoology) , lentigo , scars , dermatology , lesion , lentigo maligna melanoma , s100 protein , superficial spreading melanoma , immunohistochemistry , anatomy , cancer research
Malignant melanoma occurring in burn scars is extremely rare. Nine cases are reported in the literature. We report a case of a small malignant melanoma arising in a stable thermal burn scar after a long latent period of 58 years. The case was unique in that it was of the de novo neurotropic variant. Fascicles of amelanotic, S100 protein‐positive atypical spindle cells with neuroid appearance infiltrated deeply in the scarred dermis and perineural spaces. The pigmentation of the lesion was due to solar lentigo instead of atypical melanocytic proliferation in the overlying epidermis.