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Fibroepithelioma‐like changes associated with anogenital epidermotropic mucinous carcinoma
Author(s) -
Hurt Mark A.,
Hardarson Sverrir,
Stadecker Miguel J.,
Santa Cruz Daniel J.
Publication year - 1992
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1992.tb01355.x
Subject(s) - mucinous carcinoma , medicine , pathology , carcinoma , adenocarcinoma , cancer
We describe two patients with crusted perincal plaques that were biopsied and diagnosed as Paget's disease. Resection specimens of each contained a dermal mucinous carcinoma with extensive epidermotropism and coexistent epidermal basaloid proliferations closely resembling fibroepithelioma (Pinkus). The presence of the Paget phenomenon was supported by histochemical, immnunohistochemical, and ultrastructrual evidence. No other primary neoplasms were found in either patient. Followup at 2 1/2 and 3 1/2 years, respectively, has been negative. We conclude that either the fibroepitheliomatous changes may be induced by or may represent a collision (unlikely) with the epidermotropic mucinous carcinoma. It is proposed that the concept fibroepitheliomatous Paget phenomenon be used to stand for the histologic changes common to our cases as well as those previously reported.