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Image analysis of Stage 1 melanoma (1.00–2.50 mm): lymphocytic infiltrates related to metastasis and survival
Author(s) -
Pastorfide G. C.,
Kibbi A.G.,
Roa A. L.,
Barnhill R. L.,
Sober A. J.,
Mihm M. C.,
Byers H. R.
Publication year - 1992
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1992.tb00611.x
Subject(s) - melanoma , metastasis , medicine , pathology , stage (stratigraphy) , lymphocytic infiltration , cancer , biology , cancer research , paleontology
Image analysis of histologic sections of II patients with clinical Stage 1 melanoma, 1.00 mm – 2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic infiltrates relative to metastasis and survival. An ago, sex, site, and thickness matched control group of non‐metastasizing clinical Stage 1 melanoma revealed no significant difference in the lymphocytic infiltrate parameters from the metastasizing group with the exception of the ratio of lymphocyte infiltrate width lo the tumor width (p = 0.003). Increased lymphocytic infiltrates within the tumor and subjacent lo its base significantly correlated with delayed lime to metastasis (p = 0.014 and p < 0.001, respectively) and longer survival period (p = 0.045 and p < 0.001, respectively). Lymphocytic infiltrate area at the tumor base in relation to tumor area was of prognostic value: the larger the ratio, the greater the time interval from metastasis to death (p = 0.008).