Premium
Analysis of the 14;18 translocation in cutaneous lymphomas using the polymerase chain reaction
Author(s) -
Volkenandt M.,
Cerroni L.,
Rieger E.,
Soyer H. P.,
Koch O.,
Wienecke R.,
Atzpodien J.,
Bertino J. R.,
Kerl H.
Publication year - 1992
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1992.tb00605.x
Subject(s) - chromosomal translocation , lymphoma , polymerase chain reaction , pathology , pathogenesis , biology , b cell , gene rearrangement , medicine , gene , immunology , antibody , genetics
A series of 25 cutaneous B‐cell lymphoid proliferations was analyzed for the presence of the (14;18) translocation using the polymerase chain reaction, functional sequences of rearranged chromosomes 14 and 18 were amplified in vitro , and t (14;18) specific sequences were detected in 1 of 14 primary cutaneous B‐cell lymphomas, in 1 of 14 primary nodal B‐cell lymphomas and in none of 3 B‐cell pseudolymphomas. These results indicate that the t (14;18) may occur in a small subset of primary cutaneous lymphoma. However, the difference in incidence of the t (14;18) between primary nodal and primary cutaneous lymphomas suggests that different molecular mechanisms are involved in the pathogenesis of these lymphomas.