Premium
Localized epidermal necrolysis (erythema multiforme‐like reaction) following intravenous injection of vinblastine
Author(s) -
Arias D.,
Requena L.,
Hasson A.,
Gutierrez M.,
Domine M.,
Martin L.,
Barat A.
Publication year - 1991
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1991.tb01547.x
Subject(s) - toxic epidermal necrolysis , erythema multiforme , medicine , vinblastine , dermatology , pathology , erythema , pathogenesis , chemotherapy , surgery
We report a case of localized epidermal necrolysis that developed 24 hours after an intravenous injection of vinblastine. Clinically, the lesions consisted of erythematous macules, vesicles, and bullae with a linear arrangement over the injected vein. Histologically, the lesions showed features closely resemr bling erythema multiforme (epidermal necrolysis). We discuss, the pathogenesis of this curious cutaneous drug reaction and review the literature concerning local cutaneous complications associated with intravenously administered chemotherapeutic agents.