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Reactivity of monoclonal antibody OKM5 with sebaceous carcinoma
Author(s) -
Zhao Yuming,
Chen Hongduo,
He Chundi
Publication year - 1991
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1991.tb01543.x
Subject(s) - pagetoid , monoclonal antibody , pathology , immunoperoxidase , sebaceous carcinoma , antibody , melanoma , carcinoma , immunohistochemistry , medicine , biology , immunology , cancer research
Two cases of sebaceous carcinoma (SC), as well as epithelial tumours, melanoma, and lymphoma, were examined using immunoperoxidase and a panel of monoclonal antibodies on cryostat sections. The results showed that, whereas all SC cells in both cases reacted strongly with monoclonal antibody OK.M5, other tumour cells (except juvenile xanthogranuloma cells) did not. The pagetoid cells within the epidermis of SC also reacted with OKM5 antibody. Although the nature of the phenomenon merits further study, this reactivity, or cross‐reactivity, might possibly aid diagnosis of SC.