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Primary cutaneous adenoid cystic carcinoma: ultrastructural study and immunolocalization of Types I, III, IV, V collagens and laminin
Author(s) -
Fukai K.,
Ishii M.,
Kobayashi H.,
Chanoki M.,
Furukawa M.,
Nakagawa K.,
Hamada T.,
Abe Y.,
Ooshima A.
Publication year - 1990
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1990.tb00115.x
Subject(s) - pathology , adenoid cystic carcinoma , laminin , ultrastructure , immunohistochemistry , carcinoma , biology , medicine , extracellular matrix , microbiology and biotechnology
A primary adenoid cystic carcinoma of the skin is reported. Light microscopy revealed pseudocysts. PAS‐positive basement membrane and true glandular lumen, which in aggregates are specific for adenoid cystic carcinoma. Perineural invasion was also observed. Ultrastructural examinations revealed three types of cystic spaces; pseudocysts, true glandular lumens and intercellular spaces. Enzyme histochemical examinations showed positive reactions for eccrine enzymes, including phosphorylase and succinic dehydrogenase and negative for apocrine enzymes. Immunolocalization of collagens and laminin revealed that basement membranes of the pseudocysts involve Type V collagen as well as Type IV collagen and laminin.