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Neuropeptides in cutaneous neurofibromas of Von Recklinghausen's disease
Author(s) -
Vaalasti A.,
Suomalainen H.,
Kuokkanen K.,
Rechardt L.
Publication year - 1990
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1990.tb00114.x
Subject(s) - medicine , pathology , disease , dermatology
The occurrence of neuropeptides was studied in neurofibromas of von Recklinghausen's disease by indirect immunofluorescence. All non‐plexiform cutaneous neurofibromas contained abundant vasoactive intestinal polypeptide, peptide histidine–isoleucine and calcitonin gene‐related peptide immunoreactive nerves. The nerves were small and unmyelinated. Neuropeptides might be responsible for itch that occurs especially in small cutaneous neurofibromas. Neuropeptides are also suggested to act as modulators and/or trophic factors for neurofibroma growth.