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Immunocompetent cells and epithelial cell modifications in molluscum contagiosum
Author(s) -
Viac J.,
Chardonnet Y.
Publication year - 1990
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1990.tb00085.x
Subject(s) - molluscum contagiosum , epidermis (zoology) , monoclonal antibody , transferrin receptor , pathology , antigen , biology , keratinocyte , phenotype , beta 2 microglobulin , immunohistochemistry , cell , immunology , antibody , cell culture , medicine , anatomy , biochemistry , genetics , gene
We studied lesions of molluscum contagiosum with a panel of monoclonal antibodies to determine the phenotype of infiltrating cells and antigen modifications of infected keratinocytes. Our data indicate (1) a complete lack of immunocompetent cells in the viral lesions, and simultaneously a loss of B2‐microglobulin reactivity by molluscum bodies, a cellular activation of EGF and transferrin receptors and expression of CD36 antigen of these bodies; (2) a moderate infiltrate of activated T cells and monocytes in the underlying epidermis; (3) an increase of Langerhans cell density and a CD36 expression by the surface of upper layer keratinocytes in the perilesional epidermis.