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Immunoelectron microscopic study of the basement membrane in oral lichen planus
Author(s) -
Jungell Peter
Publication year - 1990
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1990.tb00059.x
Subject(s) - basement membrane , immunoelectron microscopy , laminin , pathology , type iv collagen , dermoepidermal junction , lamina lucida , fibronectin , basal lamina , lamina densa , anchoring fibrils , connective tissue , biology , lamina propria , staining , immunohistochemistry , chemistry , extracellular matrix , epithelium , medicine , microbiology and biotechnology , ultrastructure , dermis
The present study investigated the nature of basement membrane changes in oral lichen planus. For this purpose antibodies to type IV collagen, laminin and fibronectin were applied in avidin‐biotin peroxidase complex staining using a pre‐embed‐ding immunoelectron microscopy technique. Immunoreactivity to type IV collagen and laminin was restricted to the sub‐basal basement membrane and the basement membrane branches extending into the lamina propria. Immunoreactivity to fibronectin was noted also in the connective tissue as a network‐like arrangement of thin strands. Although local activated CDB + cytotoxic lymphocytes and tissue macrophages may be involved in the local pathogenetic process, these findings suggest that the basement membrane alterations are secondary to pathologic changes in the basal cells.