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Localized lipodystrophy with panniculitis: light and electron microscopic studies
Author(s) -
Tsuji T.,
Kosaka K.,
Terao J.
Publication year - 1989
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1989.tb00586.x
Subject(s) - adipose tissue , pathology , connective tissue , panniculitis , lipodystrophy , medicine , lesion , anti nuclear antibody , inflammation , antibody , immunology , autoantibody , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy
A 41‐year‐old woman with localized lipodystrophy histologically showed lymphohistiocytic inflammation within adipose tissue at the periphery and loss of adipose tissue in the center of the lesion. Ultrastructurally, various degrees of lipophagocytosis by macrophages and giant cells were seen, starting with the projection of cytoplasmic processes into the fat droplet and engulfing pieces of the fat droplet which finally were digested. Laboratory investigations revealed a high serum γ‐globulin level and a positive antinuclear antibody, suggestive of a connective tissue disease or autoimmue disease.