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Neurofollicular hamartoma: a light microscopic and immunohistochemical study
Author(s) -
Barr R. J.,
Goodman M. M.
Publication year - 1989
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1989.tb00582.x
Subject(s) - hamartoma , pathology , neurofibroma , immunohistochemistry , immunoperoxidase , angiofibroma , medicine , nasolabial fold , antibody , anatomy , neurofibromatosis , monoclonal antibody , immunology
Neurofollicular hamartoma is an unusual, previously undescribed neoplasm characterized by a proliferation of spindle cells and hyperplastic pilosebaceous units. Five cases were reviewed. The lesions presented as single, asymptomatic, smooth, flesh‐colored papules. Four were on the nose, and one on the adjacent nasolabial fold. Immunoperoxidase studies performed on two cases utilizing antibodies to S‐100 antigen were positive in both. These lesions share some histological and clinical features with angiofibroma and neurofibroma.