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Proliferative fasciitis: ultrastructure and histogenesis
Author(s) -
DiazFlores L.,
Martin Herrera A. I.,
Garcia Montelongo R.,
Gutierrez Garcia R.
Publication year - 1989
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1989.tb00016.x
Subject(s) - ultrastructure , histogenesis , fibroblast , giant cell , pathology , endoplasmic reticulum , biology , ground substance , nodular fasciitis , microbiology and biotechnology , extracellular , cell culture , anatomy , lesion , medicine , immunohistochemistry , connective tissue , genetics
The ultrastructure was studied of 2 cases of proliferative fasciitis (PF) which affected the fascia and subcutaneous fat. Two basic cell types were observed in the lesions: fibroblast‐like, and giant cells. The fibroblast‐like cells had myofibroblastic ultrastructural characteristics. The giant cells showed a well‐developed, rough endoplasmic reticulum, irregularly distributed filaments and clear lipid droplets in their cytoplasms. Ultrastructurally, the giant cells seemed to belong to a cellular line capable of synthesizing ground substances and extracellular fibers, but with a modified phenotype. A consistent feature was the presence of nodular aggregates of numerous proliferating perivascular cells. Transitional forms between perivascular, fibroblast‐like, and giant cells were observed. Our hypothesis is that perivascular cells (activated pericytes) are the source of the fibroblast‐like and giant cells in proliferative fasciitis.