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Erythrophagocytosis in the skin: case report
Author(s) -
Horn T. D.,
Hines H. C.,
Farmer E. R.
Publication year - 1988
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1988.tb00573.x
Subject(s) - pathology , dermis , histiocyte , peripheral blood mononuclear cell , immunoperoxidase , skin biopsy , medicine , fibrin , biopsy , biology , immunology , antibody , monoclonal antibody , biochemistry , in vitro
A 68‐year‐old male with a myclodysplastic syndrome developed a bulla on his right thigh. A skin biopsy revealed a subepider‐mal cleavage containing fibrin and a mononuclear cell infiltrate exhibiting prominent erylhrophagocytosis. Erythrophagocytosis by mononuclear cells was present, to a lesser extent, throughout the dermis and in the subcutis. Immunoperoxidase studies with anti‐lysozyme and anli‐alpha‐1‐chymotrysin confirmed the histiocytic nature of the phagocytic cells. Only a few prior reports of cutaneous erythrophagocytosis exist in the literature. In contrast to the generally grave clinical manifestations of the patients described in previous publications documenting erythrophagocytosis, this patient lacked a concomitant hematologic deterioration or serious systemic illness.