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Cutaneous IgA subclasses in dermatitis herpetiformis and linear IgA disease
Author(s) -
Wojnarowska F.,
Delacroix D.,
Gengoux P.
Publication year - 1988
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1988.tb00558.x
Subject(s) - dermatitis herpetiformis , immunoglobulin a , medicine , disease , immunology , dermatology , pathology , antibody , immunoglobulin g
The subclasses of the cutaneous IgA were studied in 8 patients with dermatitis herpetiformis and 4 with linear IgA disease. The cutaneous IgA in dermatitis herpetiformis consisted of both IgAl and IgA2, although IgAl predominated. This demonstrated that the IgA is polyclonal and may be both mucosal and blood derived. The IgA in linear IgA disease was exclusively IgA1, confirming previous work, and suggesting that mucosal IgA may not make a major contribution to the skin deposits.