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Lamellar bodies in hyperkeratosis lenticularis perstans
Author(s) -
Tidman M. J.,
Price M. L.,
MacDonald D. M.
Publication year - 1987
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1987.tb01334.x
Subject(s) - stratum spinosum , stratum granulosum , lamellar granule , pathology , lamellar ichthyosis , hyperkeratosis , ultrastructure , stratum corneum , lamellar structure , dermatology , biology , medicine , chemistry , ichthyosis , crystallography
An ultrastructural study of lesional skin from 4 subjects with hyperkeratosis lenticularis perstans (Flegel's disease) demonstrated variable numbers of lamellar bodies of normal size and architecture within cells of the stratum granulosum and the upper stratum spinosum. Their characteristic lamellate inclusions were frequently observed within the intercellular spaces. These observations suggest that the lamellar bodies are qualitatively normal in Flegel's disease.