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Peanut agglutinin immunohistochemistry of basal cell carcinoma
Author(s) -
Vigneswaran N.,
Haneke E.,
Peters K. P.
Publication year - 1987
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1987.tb00489.x
Subject(s) - immunohistochemistry , pathology , basal cell carcinoma , peanut agglutinin , medicine , basal (medicine) , agglutinin , carcinoma , basal cell , biology , immunology , lectin , insulin
103 biopsies of basal cell carcinomas (BCCs) were studied using peanut agglutinin (PNA), PNA antibody and the peroxidase‐antiperoxidase technique; 53 specimens of various skin tumors were examined as controls; 96% of the BCCs showed a band‐like peritumorous reaction not seen in any other tumor except for the Pinkus' fibroepithelioma. The peritumorous PNA‐binding was continuous in 51% of the BCCs studied and discontinuous in 45%; only 4% were completely negative. Both fibroepitheliomas revealed a discontinuous PNA‐positive band. A narrow basement membrane‐like positivity was seen around some small hair follicles situated within 2 neurofibromas and under one seborrhoeic keratosis. The PNA‐binding band is apparently neither fibronectin, laminin, Type IV or Type V collagen and is not a constituent of normal epidermal, adnexal and vascular basement membranes.