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Generalized eruptive histiocytoma: an ultrastructural study
Author(s) -
Shimizu N.,
Ito M.,
Sato Y.
Publication year - 1987
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1987.tb00480.x
Subject(s) - pathology , histiocyte , vacuole , cytoplasm , ultrastructure , biology , medicine , microbiology and biotechnology
A case of generalized eruptive histiocytoma (GEH) was evaluated and examined histopathologically and ultrastructurally. A 24‐year‐old male had an episode of high fever and drug‐induced eruption prior to the appearance of multiple skin lesions. Uniform, red to dark‐red papular lesions appeared on his cheeks and then became generalized. The lesions were composed of a massive dermal infiltrate of histiocytes, which had oval nuclei and amphophilic cytoplasm. The cytoplasm contained unique annular structures, myeloid bodies and vacuoles. The specificity of these structures is as yet unknown. Reactive stimulation rather than neoplastic proliferation may be a causative factor in GEH.