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Malignant transformation of eccrine tumors
Author(s) -
Galadari E.,
Mehregan A. H.,
Lee K. C.
Publication year - 1987
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1987.tb00122.x
Subject(s) - cylindroma , pathology , malignant transformation , squamous metaplasia , basement membrane , sweat gland , adenoma , hidradenoma , metaplasia , eccrine sweat gland , medicine , epithelium , sweat
Malignant transformation occurred in pre‐existing sweat gland tumors in 7 patients. Three lesions showed an histologic pattern of eccrine spiradenoma, 2 eccrine poroma, one cylindroma and one papillary eccrine adenoma. Malignant transformation was histologically characterized by the presence of solid tumor areas populated with large cells having irregularly shaped nuclei and mitotic figures. There were multiple foci of squamous metaplasia, areas of loss of basement membrane and invasion of the surrounding connective tissue.