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Granular‐cell tumours of the skin do not express carcino‐embryonic antigen
Author(s) -
Kanitakis J.,
Zambruno G.,
Viac J.,
Thivolet J.
Publication year - 1986
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1986.tb00472.x
Subject(s) - histogenesis , immunoperoxidase , carcinoembryonic antigen , pathology , immunohistochemistry , antigen , embryonic stem cell , biology , medicine , antibody , immunology , monoclonal antibody , cancer , biochemistry , gene , genetics
Granular‐cell tumour (GCT) of the skin is an uncommon tumour of disputed histogenesis, that has been subjected to several immunohistochemical studies. The controversy existing in the literature concerning the expression of carcinoembryonic antigen (CEA) by GCT prompted us to study a series of 17 cases of cutaneous GCT by using an avidin‐biotin‐immunoperoxidase technique on routinely‐processed tissue sections. No CEA activity was detected in any of the tumours screened. The reasons for this controversy are discussed.