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Markers of immunologic injury in progressive alopecia areata
Author(s) -
PeereboomWynia J. D. R.,
Joost Th.,
Stolz E.,
Prins M. E. F.
Publication year - 1986
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1986.tb00471.x
Subject(s) - alopecia areata , medicine , disease , pathology , alopecia universalis , immunology
In a selected group of 8 patients with progressive alopecia areata (AA) leading to AA universalis, immunological aspects (in the peripheral blood and the tissue) were studied during the period of the intitial attack of the disease. The peripheral T‐cell helper/suppressor ratio appeared not to be a reliable parameter for the disease activity. The intrabulbar and peribulbar distribution of T‐cells, Langerhans cells and of HLA‐DR expression in and around the anagen hair follicles in the progressive areas of the disease (region of exclamation‐mark hairs) may suggest a T‐cell‐mediated injury primarily in the peribulbar regions of the follicles. The data presented tend to support the possibility that in the early development of AA, the dermal pailla (capillary network?) may be the prime target of immunologic injury.