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Primary neuroendocrine carcinoma and small‐cell malignant lymphoma of the skin
Author(s) -
Wick M. R.,
Kaye V. N.,
Sibley R. K.,
Tyler R.,
Frizzura G.
Publication year - 1986
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1986.tb00469.x
Subject(s) - pathology , lymphoma , antigen , immunohistochemistry , pseudolymphoma , monoclonal antibody , medicine , stain , carcinoma , large cell , adenocarcinoma , antibody , staining , cancer , immunology
In selected instances, primary cutaneous neuroendocrine carcinoma (PCNEC) and small‐cell malignant lymphoma (SGML) of the skin may display similar clinical presentations and microscopic appearances, leading to diagnostic uncertainty. We applied monoclonal antibodies to epithelial membrane antigen (EMA), la antigen, and leukocyte common antigen (LCA) to 31 cases of PCNEC and J2 of small‐cell lymphoma cutis, using a combined PAP and ABC procedure, to determine whether or not such stains were capable of separating the two neoplasms. All cases og SCML were reactive for LCA, while this determinants was not seen in any example of PCNEC. Anti‐la antigen labelled 11 of 12 cases of SGML, and also failed to stain neuroendocrine carcinomas. Lastly, EMA was observed in 25 of 31 cases of PCNEC, but it was found in one lymphoplasmacytoid lymphoma as well. Bayes'univariate statistical analysis of these data indicates that anti‐LCA, anti‐EMA. and anti‐la antigen arc capable of discriminating between the tumors in question, with anti‐LCA being the most effective.