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Non‐polarizable collagen in dermatofibrosarcoma protuberans: a useful diagnostic aid
Author(s) -
Barr R. J.,
Young E. M.,
King D. F.
Publication year - 1986
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1986.tb00468.x
Subject(s) - dermatofibrosarcoma protuberans , dermatofibrosarcoma , pathology , medicine , dermatopathology , dermatology
The stroma in dermatofibrosarcoma protuberans (DFSP) stains with trichrome, but is not polarizable (birefi ingeiit. doubly retractile). The usefulness of polarizing neo‐plastic stroma as a diagnostic aid in distinguishing DFSP from dermatofibroma and fibromatosis was evaluated. Forty cases of dermatofibroma of all types, 12 cases of dermal fibromatosis, and 15 cases of DFSP were examined. None of the DFSPs contained polarizable collagen, whereas 11 of the 12 (92%) fibromatoses and 35 of the 40 (88%) dermatofibromas did. Of the 5 dermatofibromas that did not polarize, all were composed primarily of round to polyhedral histiocytic cells, including foam cells, frequently surrounding small obliterated capillaries. Although not puthognomonic, the presence of nonpolarizable collagen appears to he an additional histological marker useful in differentiating DFSP from dermatofibroma and fibromatosis.