Premium
A study of intermediate filaments (cytokeratin, vimentin, neurofilament) in two cases of Merkel cell tumor
Author(s) -
Dreno B.,
Mousset S.,
Stalder J. F.,
Bureau B.,
Litoux P.,
Barrièare H.
Publication year - 1985
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1985.tb00428.x
Subject(s) - neurofilament , cytokeratin , vimentin , merkel cell , intermediate filament , pathology , monoclonal antibody , immunohistochemistry , keratin , biology , immunocytochemistry , cytoskeleton , cell , antibody , medicine , merkel cell carcinoma , immunology , carcinoma , genetics
In two cases of Merkel cell tumor, the study of intermediate filaments, using monoclonal antibodies (vimentin, cytokeratin, neurofilaments), confirmed the double differentiation (neuroendocrine and epithelial) of this tumor as previously observed in histological, electron microscopical and histochemical analyses. Labelling of the tumor cells was positive with monoclonal antibodies against neurofilament proteins and cytokeratin.