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Direct and indirect immunofluorescent findings in dermatomyositis
Author(s) -
Chen Z.,
Maize J. C.,
Silver R. M.,
Dobson R.L.,
Maricq H. R.,
Ainsworth S. K.
Publication year - 1985
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1985.tb00425.x
Subject(s) - dermatomyositis , pathology , medicine , anti nuclear antibody , forearm , immunofluorescence , antibody , radioimmunoassay , direct fluorescent antibody , immunodiffusion , autoantibody , immunology
Three skin biopsies (proximal nailfold, extensor forearm and buttock) and serum samples were studied by direct and indirect immunofluorescence, immunodiffusion and radioimmunoassay techniques in 6 patients with dermatomyositis. A variety of seroligic and immunopathologic abnormalities was observed in the patients. Three of ft patients had antinuclear antibodies (ANA) of a speckled pattern mixed with a peculiar dot pattern. Epidermal intercellular deposits of immunoglobulins were seen in the nailfold biopsies of 2 patients; one of them also had IgG deposits in the cytoplasm of epidermal cells. Forearm and buttock biopsies were negative.