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Acute disseminated histiocytosis‐X: in situ immunophenotyping with monoclonal antibodies
Author(s) -
Bos J. D.,
Sillevis Smitt J. H.,
Krieg S. R.,
Bakker P. M.,
Vos G. D.,
Zaane D. J.
Publication year - 1984
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1984.tb00350.x
Subject(s) - pathology , histiocyte , immunoperoxidase , monoclonal antibody , histiocytosis x , histiocytosis , stain , immunophenotyping , medicine , antibody , staining , malignant histiocytosis , antigen , immunology , disease
The proliferating skin cells in a case of acute disseminated histiocytosis‐X (Abt‐Letterer‐Siwe disease) confirmed by electron microscopy, were characterized by a panel of monoclonal antibodies using an immunoperoxidase technique. The “histiocytes” were found to stain with OKT‐6 (anti‐T6) and anti‐HLA‐DR antibodies. Unexpectedly, slight staining was also observed with Leu 3a (anti‐T4) and OKM‐1. A proliferative process of T4, T6, HLA‐DR, OKM‐1 positive Langerhans' cells has not yet been described and may be specific for histiocytosis‐X.