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Presence of fibroblast‐type intermediate filaments (vimentin) and absence of neurofilaments in pigmented nevi and malignant melanomas
Author(s) -
Miettinen M.,
Lehto V.P.,
Virtanen I.
Publication year - 1983
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1983.tb00325.x
Subject(s) - vimentin , intermediate filament , neurofilament , desmin , keratin , pathology , glial fibrillary acidic protein , intermediate filament protein , cytoskeleton , melanoma , biology , chemistry , immunohistochemistry , medicine , cancer research , cell , genetics
The cytoskeletal intermediate filaments of pigmented nevi and malignant melanomas (nine cases of each) were evaluated using monospecific antibodies against intermediate filament proteins and immunofluorescence microscopy. Both pigmented nevi and cutaneous malignant melanomas showed only vimentin‐type intermediate filaments, hut not keratin, neurofilaments, desmin or glial fibrillary acidic protein. Thus, nevi and melanomas do not show neural characteristics in the cytoskeletal intermediate filament pattern although they appear lo show other neural markers. Vimentin – content in melanomas versus keratin – content in carcinomas may he used as a differential diagnostic feature.