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Light and electron microscopy of psoriatic skin before and during retinoid (Ro 10–9359) and retinoid‐PUVA treatment
Author(s) -
Kanerva Lasse,
Lauharanta Jorma,
Niemi KirstiMaria,
Lassus Allan
Publication year - 1982
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1982.tb01054.x
Subject(s) - retinoid , etretinate , psoriasis , pathology , epidermis (zoology) , puva therapy , dermatology , vitiligo , keratinocyte , melanosome , electron microscope , desmosome , medicine , chemistry , cell , anatomy , retinoic acid , melanin , biochemistry , physics , optics , in vitro , gene
High patients with psoriasis (pustular, erythrodermic or severe plaque type) were treated sucessfully with retinoid (Ro 10‐9359) or with retinoid followed by PUVA (RePUVA). The histological changes in recovering skin were examined during 14 weeks. Treatment resulted in normalization of keratinocyte differentiation with fine structural changes suggesting decreased metabolic activity and a reduction of mitoses. There was an increase in the number of keratohyalin granules and of tonofilaments and desmosomes and a decrease in leukocytes in the epidermis. The different cell organelles were studied in detail, but the exact mechanism of retinoid action remains unsolved. Although the treatments were clinically highly effective, total normalization of the histological and electron microscopical picture was not achieved.