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Effects of the Hypoxic Radiosensitizer Misonidazole on Normal and Irradiated Epidermis
Author(s) -
Rey B. M.,
Lanfranchi H. E.,
KleinSzanto A. J. P.,
Itoiz M. E.
Publication year - 1981
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1981.tb00991.x
Subject(s) - misonidazole , epidermis (zoology) , radiosensitizer , irradiation , in vivo , pathology , basal (medicine) , chemistry , medicine , cancer research , radiation therapy , in vitro , biology , anatomy , biochemistry , physics , microbiology and biotechnology , nuclear physics , insulin
Misonidazole, a hypoxic cell radiation‐sensitizer, has been used in vivo to analyze its effects on normal and x‐radiation epidermis. The drug action was evaluated 3 days after being implanted subcutaneously. The response of the epidermis and especially of the basal cells to the drug alone and in combination with x‐radiation was studied. The ultramorphological analysis as well as quantitative data on epidermal thickness and keratinocyte volume showed that high doses of misonidazole impair the usual post‐irradiation epidermal reaction, thus enhancing the involutional effects of radiation and inhibiting radiation‐damage repair, even under conditions of normal oxygenation.