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Langerhans Cells in Dermoid Cysts: Transmission Electron Microscopic, Cytochemical and Immunofluorescent Observations
Author(s) -
Shah Kishor H.,
More Newton S.,
Queen William,
Rusnock Eileen,
Rowden Geoffrey
Publication year - 1981
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1981.tb00985.x
Subject(s) - birbeck granules , pathology , keratin , staining , biology , langerhans cell , antigen , immunology , medicine
Langerhans cells were detected in squamous, stratified epithelia lining human dermoid cysts. Their presence was assayed by ATPase staining and reactivity with heteroantisera against “Ia‐like” antigens. Transmission electron microscopic; studies demonstrated variations in the numbers of cells showing Birbeck granules in epithelia with different degrees of keratinzation. Indeterminate cells (i.e. lacking granules), were more frequent in epithelia showing combined mucous and keratinizing differentiation. Membrane‐coating‐granules and keratohyalin granules were present in epithelia containing Langerhans cells with clearly identifiable Birbeck granules. Interepithelial mast cells were observed in epithelia with mucous differentiation. A relationship between Langerhans cells and kerutinization was suggested. Such non‐immune functions are compatible with the known macrophage characteristics of the cell.