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“Lumpy‐Bumpy” Elastic Fibers in the Skin and Lungs of a Patient with a Penicillamine‐Induced Elastosis Perforans Serpiginosa
Author(s) -
BARDACH H.,
GEBHART W.,
NIEBAUER G.
Publication year - 1979
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1979.tb01131.x
Subject(s) - penicillamine , pathology , lung , medicine , collagen fibres , dermatology
Penicillamine‐induced cutaneous elastosis perforans serpiginosa associated with a large air‐cyst in the right lung is described in a 29‐year‐old female patient with Wilson disease. Identical light and electron‐microscopic changes were present in both dermal and pulmonary elastic tissue, suggesting a disseminated drug‐induced cutaneo‐visceral elastosis. Lung cysts have not been previously reported in association with long term penicillamine treatment. The electron‐microscopic morphology of the elastic fibers was found to be “specific” enough to allow separation of penicillamine‐induced elastosis perforans serpiginosa from other forms of this disease.