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Cell Proliferation in the Lichen Planus Infiltrate
Author(s) -
EBNER HERWIG,
JURECKA WOLFGANG
Publication year - 1977
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1977.tb00906.x
Subject(s) - histiocyte , pathology , electron microscope , peripheral blood mononuclear cell , thymidine , chemistry , cell , biology , medicine , dna , biochemistry , physics , optics , in vitro
In seven patients suffering from lichen planus (LP) light‐ and electron‐microscopic 3 H‐thymidine ( 3 HT) labeling studies were performed and the following results were obtained. 1. Using the light‐microscope, a large number of 3 HT labeled cells can be observed in the dermal infiltrate of LP. Most of the labeled nuclei belong to mononuclear, ‘round cells’ while isolated endothelial cells. fibroblasts, histiocytes and mast cells could be found labeled. 2. The mean labeling index of ‘round cells’ in our patients was 4.27 ± 1.57%. 3. The evaluation of the electron microscopic autoradio‐graphs showed that, as far as ‘round’ cells were concerned, exclusively nuclei of cells showing the morphological criteria of stimulated lymphocytes were labeled. These findings support the view that in LP, as in allergic contact dermatitis, a high proliferative activity of lymphocytes takes place.