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Cutaneous Nerve Lesions in Prurigo Nodularis
Author(s) -
Sandbank Miriam
Publication year - 1976
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1976.tb01103.x
Subject(s) - prurigo nodularis , pathology , neurofilament , medicine , cutaneous nerve , schwann cell , electron microscope , anatomy , cytoplasm , biology , immunohistochemistry , dermatology , microbiology and biotechnology , physics , optics
Skin biopsies from two patients with prurigo nodularis were studied with the electron microscope. Lesions were found in the cutaneous myelinated and unmyelinated nerves. Schwann‐cell cytoplasm showed large irregular, membrane‐bound, electron‐lucent vacuoles. Unmyelinated axons were distended and devoid of neurotubules and neurofilaments. Myelinated nerves showed various degrees of demyelination. Onion‐bulb formations with a centrally located myelinated fibre were also observed and numerous mast cells were found in the cellular infiltrate. All these findings indicate the presence of a chronic peripheral neuropathy, the etiology of which remains to be determined.