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Iodoxuridine in Dimethyl Sulfoxide: is it Carcinogenic in Man?
Author(s) -
Thomson John,
O'neill S. M.
Publication year - 1976
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1976.tb00875.x
Subject(s) - dimethyl sulfoxide , carcinogen , discontinuation , pathology , dermatology , medicine , chemistry , organic chemistry
When iodoxuridine (IDU) – carried in dimethylsulfoxide (DMSO) – was topically applied on penile lesions suspected to be herpes simplex, premalignant epidermal changes developed. Discontinuation of treatment resulted in complete healing. It seems wise when IDU in DMSO is used for similar cases, to consider this treatment experimental because both constituents of this preparation are, in theory, potentially carcinogenic.