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Ultrastructural Localization of Acid Phosphatase in Normal and X‐lrradiated Epidermis
Author(s) -
Rey B. M.,
Itoiz M. E.,
Frasch A. C. C.,
Cabrini R. L.
Publication year - 1976
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1976.tb00843.x
Subject(s) - acid phosphatase , epidermis (zoology) , ultrastructure , epithelium , keratin , pathology , alkaline phosphatase , electron microscope , irradiation , biology , phosphatase , chemistry , biochemistry , anatomy , enzyme , medicine , physics , nuclear physics , optics
Acid phosphatase activity has been studied in normal and X‐irradiated rat epidermis. A remarkable reaction increment was found in irradiated epithelium at the granular layer keeping the same pattern of distribution observed in the normal tissue. No reactive lysosomes or keratinosomes were observed in the cytochemical sections, while many keratinosomes but no lysosomes appeared in the electron microscopic preparations of irradiated animals. Irradiated epithelium is discussed as a suitable model to analyze the role of acid phosphatase in the keratinization mechanisms.