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In vitro synthesis of paraproteins in pathological skin
Author(s) -
Lai A Fat R. F. M.
Publication year - 1974
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1974.tb00197.x
Subject(s) - paraproteins , paraproteinemia , pathology , multiple myeloma , bence jones protein , in vitro , medicine , immunofluorescence , bone marrow , pathological , immunology , chemistry , antibody , monoclonal , immunoglobulin light chain , biochemistry , monoclonal antibody
Two cases are reported, one of multiple myeloma and the other of erythrodermia (malignant reticulosis?), the former associated with a Bence‐Jones paraprotein and the latter with IgM paraproteinemia. With an in vitro culture technique and/or the immunofluorescence method it could be demonstrated that the paraprotein present in the serum was synthesized not only in the bone marrow but also in the lesional skin.