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Immunoregulation of skin sensitization and regulatory T cells
Author(s) -
Kimber Ian,
Travis Mark A.,
Martin Stefan F.,
Dearman Rebecca J.
Publication year - 2012
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2012.02148.x
Subject(s) - sensitization , skin sensitization , immunology , allergic contact dermatitis , immune system , medicine , phenotype , allergy , contact dermatitis , regulatory t cell , biology , t cell , gene , biochemistry , il 2 receptor
It is well established that, in common with other adaptive immune responses, the acquisition of skin sensitization is carefully orchestrated and finely controlled. This is achieved in a number of ways. However, in recent years, there has been an increasing interest in the roles that regulatory T cells (Tregs) play in allergic contact dermatitis. Here, we review briefly the phenotype and function of Tregs, and consider how they may impact on various aspects of skin sensitization, including: inter‐individual differences in susceptibility; variations in the potency of chemical allergens; and the prevention of excessive, and potentially damaging, levels of sensitization.