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Is hydroxyisohexyl 3‐cyclohexene carboxaldehyde sensitization declining in central Europe?
Author(s) -
Schnuch Axel,
Geier Johannes,
Uter Wolfgang
Publication year - 2012
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2012.02126.x
Subject(s) - library science , medicine , art history , history , computer science
In several studies conducted during the last decade, the synthetic fragrance hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC; CAS 31906-04-4) has been shown to be a frequent sensitizer, with a prevalence of >2% among patients tested (1–6). Recent publications, however, have reported prevalences of sensitization of <2%, both in Denmark (7) and in Germany (8). However, in the most recent re-analysis (9) of the original data from the Gentofte Hospital in Denmark (7), the declining trend was not confirmed. The present article focuses on a time trend analysis of HICC contact sensitization based on Information Network of Departments of Dermatology (IVDK) data registered between 2002 and 2011.