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Changing delayed‐type sensitizations to the baseline series allergens over a decade at the Zurich University Hospital
Author(s) -
Janach Ma,
Kühne Andreas,
Seifert Burkhardt,
French Lars E.,
BallmerWeber Barbara,
Hofbauer Günther F. L.
Publication year - 2010
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2010.01727.x
Subject(s) - lanolin , sensitization , medicine , dermatology , allergy , patch test , immunology , chemistry , chromatography
Background: Patch testing detects delayed‐type sensitizations and may show changes in prevalence over time. Objectives: To compare sensitization prevalence to our baseline series allergens during the years 2000–2004 to results from 1990 to 1994. Methods: We analysed baseline patch test series allergens from 2000 through 2004. Results: 4094 individuals were patch tested to the baseline series (mean age 45.4 years, males 41.7%). The highest sensitization rates were found for nickel sulfate (19.3%), fragrance mix (10.4%) and Myroxylon pereirae (7.8%). Compared to 1990–1994, methylchloroisothiazolinone (and) methylisothiazoline (MCI/MI) and neomycin sulfate sensitization decreased and lanolin alcohol, thiuram mix and ammoniated mercury sensitization increased. Conclusions: Current sensitization rates are similar to those across Europe. Reduced sensitizations to MCI/MI and neomycin sulfate and increased sensitizations to thiuram mix and ammoniated mercury chloride may well be because of changes in exposure. The current group comprises a higher proportion affected by leg dermatitis and may thus explain the higher sensitization to lanolin alcohol. Comparing patch results over time shows important changes in sensitization prevalence.