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Interleukin‐1 receptor antagonist and tumour necrosis factor‐alpha gene polymorphisms in Turkish patients with allergic contact dermatitis
Author(s) -
Ertam Ilgen,
Itirli Gulcin,
Onay Huseyin,
Alper Sibel,
Ozkinay Ferda
Publication year - 2009
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2009.01593.x
Subject(s) - genotype , medicine , immunology , allergic contact dermatitis , atopic dermatitis , gene polymorphism , contact dermatitis , polymorphism (computer science) , interleukin , dermatology , allergy , gene , biology , genetics , cytokine
Background: It has been shown that the family of interleukin‐1 receptor antagonist (IL‐1 RA) and tumour necrosis factor‐alpha (TNFα) genes are polymorphic and related to some inflammatory diseases. Allergic contact dermatitis is the classic presentation of delayed‐type hypersensitivity responses to exogenous agents. A number of genes playing role in inflammatory response may be associated with allergic contact dermatitis. Objectives: To investigate whether there is an association between IL‐1RA and TNFα gene polymorphisms and allergic contact dermatitis in Turkish patients with allergic contact dermatitis. Methods: This study was performed by the collaboration of Departments of Dermatology and Medical Genetics, Ege University, Faculty of Medicine. A total of 50 patients (31 females and 19 males) with allergic contact dermatitis, and 100 age‐ and sex‐matched controls (58 females and 42 males) were included in the study. IL‐1RA Variable Number of Tandem Repeats (VNTR) polymorphism in intron 2 and TNFα‐308G‐A polymorphism were genotyped by using polymerase chain reaction and agarose gel electrophoresis. Results: The frequency of IL‐1RA 1/2 (48%) genotype was significantly higher ( P = 0.002) in patient group than that is found in control group (22%). The frequency of TNFα (TNF G‐308A) G/G genotype was significantly higher in patient group (68%) than that is found in control group (31%) ( P = 0.008). Conclusions: Our findings suggest that TNFα (G/G) gene polymorphism may play role in susceptibility to allergic contact dermatitis in Turkish patients.