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Contact allergy to epoxy (meth)acrylates
Author(s) -
AaltoKorte Kristiina,
Jungewelter Soile,
HenriksEckerman MajLen,
Kuuliala Outi,
Jolanki Riitta
Publication year - 2009
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2009.01574.x
Subject(s) - epoxy , bisphenol a , meth , propane , diglycidyl ether , contact allergy , allergic contact dermatitis , allergy , polymer chemistry , materials science , chemistry , contact dermatitis , organic chemistry , acrylate , medicine , polymer , immunology , monomer
Background: Contact allergy to epoxy (meth)acrylates, 2,2‐bis[4‐(2‐hydroxy‐3‐methacryloxypropoxy) phenyl]propane (bis‐GMA), 2,2‐bis[4‐(2‐hydroxy‐3‐acryloxypropoxy)phenyl]‐propane (bis‐GA), 2,2‐bis[4‐(methacryl‐oxyethoxy)phenyl] propane (bis‐EMA), 2,2‐bis[4‐(methacryloxy)phenyl]‐propane (bis‐MA), and glycidyl methacrylate (GMA) is often manifested together with contact allergy to diglycidyl ether of bisphenol A (DGEBA) epoxy resin. Objective: To analyse patterns of concomitant allergic reactions to the five epoxy (meth)acrylates in relation to exposure. Methods: We reviewed the 1994–2008 patch test files at the Finnish Institute of Occupational Health (FIOH) for reactions to the five epoxy (meth)acrylates, and examined the patients' medical records for exposure. Results: Twenty‐four patients had an allergic reaction to at least one of the studied epoxy (meth)acrylates, but specific exposure was found only in five patients: two bis‐GMA allergies from dental products, two bis‐GA allergies from UV‐curable printing inks, and one bis‐GA allergy from an anaerobic glue. Only 25% of the patients were negative to DGEBA epoxy resin. Conclusions: The great majority of allergic patch test reactions to bis‐GMA, bis‐GA, GMA and bis‐EMA were not associated with specific exposure, and cross‐allergy to DGEBA epoxy resin remained a probable explanation. However, independent reactions to bis‐GA indicated specific exposure. Anaerobic sealants may induce sensitization not only to aliphatic (meth)acrylates but also to aromatic bis‐GA.