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Can simultaneous contact allergies to phenyl glycidyl ether and epoxy resins of the bisphenol A/F‐types be explained by contamination of the epoxy resins?
Author(s) -
Pontén Ann,
Zimerson Erik,
Bruze Magnus
Publication year - 2008
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2008.01420.x
Subject(s) - epoxy , bisphenol a , diglycidyl ether , bisphenol , contact allergy , chemistry , contact dermatitis , polymer chemistry , allergy , organic chemistry , medicine , immunology
Background: Simultaneous contact allergies to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA‐R) or epoxy resins of the bisphenol F‐type and the reactive diluent phenyl glycidyl ether (PGE) have been reported. The reason might be cross‐reactivity, exposure to an epoxy resin system with PGE as a component, or contamination by PGE in the epoxy resin. Aims: To study contamination by PGE, 20 commercial epoxy resins were analysed for the presence of PGE. To study contact allergy to PGE and its relation to epoxy resins by inserting PGE in the standard series. Results: Among 2227 patients, 7 reacted to PGE. Of 23 (30%) patients, 7 with contact allergy to DGEBA‐R and 7/19 (37%) with contact allergy to an epoxy resin of the bisphenol F‐type reacted to PGE. All 7 patients with contact allergy to PGE reacted both to the DGEBA‐R and to the epoxy resin of the bisphenol F‐type. PGE was found in 90% of the investigated resins. The amounts of PGE ranged between 0.004% w/w and 0.18% w/w. Conclusion: Most probably, the presence of PGE as a contaminant in epoxy resins is of minor importance for the sensitization, but possibly the contamination of PGE might elicit contact dermatitis in individuals with a high reactivity to PGE.