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Dicaprylyl maleate – an emerging cosmetic allergen
Author(s) -
Lotery Helen,
Kirk Stephen,
Beck Michael,
Burova Ekaterina,
Crone Mary,
Curley Reginald,
Downs Anthony,
Hill Glenda,
Horne Helen,
Iftikhar Nadia,
Lovell Christopher,
Malanin Ken,
Orton David,
Powell Sheila,
Sansom Jane,
Sonnex Timothy,
Todd David,
Tucker Simon,
Wilkinson Mark,
Haworth Adam
Publication year - 2007
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.2007.01184.x
Subject(s) - medicine , patch testing , allergen , patch test , cosmetics , contact dermatitis , dermatology , allergy , allergic contact dermatitis , contact allergy , immunology , pathology
Dicaprylyl maleate (DCM) has been reported rarely as a cause of allergic contact dermatitis. The objectives of this study were to identify patients from multiple centres with allergy to DCM in cosmetic products confirmed by patch testing and, in addition, to investigate the effect of testing with aged DCM. This is an international multicentre study of 22 patients with 26 reactions to products containing DCM. Patch testing was carried out to ingredients including DCM obtained from the manufacturer. Further testing was carried out with deliberately aged DCM in a sample of patients. 22 patients had clinical and positive patch test reactions at 4 days to a total of 26 cosmetic products containing DCM. 5 patients did not react to DCM prepared by the manufacturer from concurrent factory stock but did have positive reactions to a deliberately aged batch of DCM. DCM is an emerging cosmetic allergen. Testing with aged material yields a greater number of positive results. Co‐operation between cosmetics manufacturers and clinicians is important in the identification of new allergens.